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|Tested species reactivity||Fruit fly , Mouse , Rabbit , Rat , Human , Clawed frog|
|Published species reactivity||Fish , Human|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Equine Cytochrome c.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Morphine stimulates nitric oxide release in human mitochondria.
33-8500 was used in western blot to discuss morphinergic/NO-coupled regulation.
|Stefano GB,Mantione KJ,Capellan L,Casares FM,Challenger S,Ramin R,Samuel JM,Snyder C,Kream RM||Journal of bioenergetics and biomembranes (47:409)||2015|
Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress.
||Risso-de Faverney C,Orsini N,de Sousa G,Rahmani R||Aquatic toxicology (Amsterdam, Netherlands) (69:247)||2004|
Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
||Reiss U,Oskouian B,Zhou J,Gupta V,Sooriyakumaran P,Kelly S,Wang E,Merrill AH,Saba JD||The Journal of biological chemistry (279:1281)||2004|
The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.
33-8500 was used in immunoprecipitation to study the interaction between BRCA1 tumor suppressor and inositol 1,4,5-trisphosphate receptors and its effect on apoptotic calcium release.
|Hedgepeth SC,Garcia MI,Wagner LE,Rodriguez AM,Chintapalli SV,Snyder RR,Hankins GD,Henderson BR,Brodie KM,Yule DI,van Rossum DB,Boehning D||The Journal of biological chemistry (290:7304)||2015|
Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma.
||Birks SM,Danquah JO,King L,Vlasak R,Gorecki DC,Pilkington GJ||Neuro-oncology (13:950)||2011|
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase.
||Love DC,Kochan J,Cathey RL,Shin SH,Hanover JA,Kochran J||Journal of cell science (116:647)||2003|
THC4, CYC, HCS
cytochrome c, somatic-like, cytochrome c, somatic, cytochrome c, CYC, HCS, THC4