MA5-11674 targets Cytochrome c in IHC (P) and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11674 immunogen is synthetic peptides corresponding to amino acids 1-80, 81-104 and 66-104 of pigeon cytochrome c.
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
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Protein Aliases: Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic
Gene Aliases: CYC; CYCS; CYCSA; HCS; THC4