Positive control: Squamous oesophagus cancer.
When used in conjunction with CYP3A7 (Product #X2048M), can differentiate between the CYP3A family members, 3A5 and 3A7.
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aryl hydrocarbon hydroxylase; CYPIIIA5; Cytochrome P450 3A5; cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; Cytochrome P450-PCN3; flavoprotein-linked monooxygenase; HLp2; microsomal monooxygenase; P450-PCN3; xenobiotic monooxygenase
Gene Aliases: CP35; CYP3A5; CYPIIIA5; P450PCN3; PCN3
UniProt ID: (Human) P20815
Entrez Gene ID: (Human) 1577
Molecular Function: oxygenase