Immunogen sequence: MEEDDSYVPS DLTAEERQEL ENIRRRKQEL LADIQRLKDE IAEVANEIEN LGSTEERKNM QRNKQVAMGR; Positive Samples: Raji, Mouse brain, Mouse heart, Mouse spleen, Rat heart; Cellular Location: Cell membrane, Cytoplasm, Peripheral membrane protein, cytosol
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.
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Protein Aliases: CLM1; cytoadhesin 1; Cytohesin-1; FLJ34050; FLJ41900; homolog of secretory protein SEC7; mSec7-1; PH, SEC7 and coiled-coil domain-containing protein 1; pleckstrin homology, Sec7 and coiled-coil domains 1; pleckstrin homology, Sec7 and coiled/coil domains 1(cytohesin 1); rSec7-1; SEC7 homolog A; SEC7 homolog B2-1
Gene Aliases: B2-1; CLM1; CTH-1; CYTH1; CYTIP; CYTOHESIN-1; D17S811E; mKIAA4240; PSCD1; SEC7; Sec7a