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|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human GRP1 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25552 detects Cytohesin 3 from human and rat samples.
MA1-25552 has been successfully used in immunocytochemistry, and Western blot procedures.
The MA1-25552 immunogen is recombinant, full length human GRP1 protein.
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ARF nucleotide-binding site opener 3; ARNO3; cytohesin-3; general receptor of phosphoinositides 1; GRP1; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology, Sec7 and coiled-coil domains 3; pleckstrin homology, Sec7 and coiled/coil domains 3; PSCD3; rSec7-3; SEC7 homolog C
ARNO3; CYTH3; GRP1; PSCD3; Sec7; Sec7C