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NeoBiotechnologies
Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CK-10; CK-13; cytokeratin 10; cytokeratin 13; Cytokeratin-10; Cytokeratin-13; K10; K13; keratin 10, type I; keratin 13, type I; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin-10; Keratin-13
Gene Aliases: BCIE; BIE; CK10; CK13; EHK; K10; K13; KPP; KRT10; KRT13; WSN2
UniProt ID: (Human) P13645, (Human) P13646
Entrez Gene ID: (Human) 3858, (Human) 3860
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