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|Tested species reactivity||Human, Pig|
|Published species reactivity||Sheep, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Cytoskeletal extract from epidermis of normal human skin.|
|Storage buffer||tissue culture supernatant diluted in PBS|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||1/50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase. A suggested positive control for immunohistochemical applications is human normal skin.
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Interactions between myofibroblast differentiation and epidermogenesis in constructing human living skin equivalents.
MA1-81470 was used in immunohistochemistry to use a human living skin equivalents model to study myofibroblast differentiation and epidermogenesis
|Yang L,Hashimoto K,Tohyama M,Okazaki H,Dai X,Hanakawa Y,Sayama K,Shirakata Y||Journal of dermatological science (65:50)||2012|
New skin-equivalent model from de-epithelialized amnion membrane.
MA1-81470 was used in immunohistochemistry to develop a living skin-equivalent from de-epithelialized amnion membrane
|Yang L,Shirakata Y,Shudou M,Dai X,Tokumaru S,Hirakawa S,Sayama K,Hamuro J,Hashimoto K||Cell and tissue research (326:69)||2006|
The hsp27kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation.
MA1-81470 was used in immunocytochemistry to investigate the important role of hsp27 protein in epidermal differentiation
|Jonak C,Mildner M,Klosner G,Paulitschke V,Kunstfeld R,Pehamberger H,Tschachler E,Trautinger F||Journal of dermatological science (61:32)||2011|
Isolation and characterization of putative epidermal stem cells derived from Cashmere goat fetus.
MA1-81470 was used in immunocytochemistry to characterize the putative epidermal stem cells from Cashmere goat fetus
|Islam MS,Zhou H||European journal of dermatology : EJD (17:302)||2007|
CK-10; cytokeratin 10; keratin, type I cytoskeletal 10; keratin-10
BCIE; BIE; CK10; EHK; K10; KPP