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|Tested species reactivity||Human , Mouse , Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the N-terminus of human Cytokeratin 14|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 52 kDa.
Purity is >95% by SDS-PAGE.
In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CK 14; CK 16; CK-14; CK-16; CK14; CK16; Cytokeratin 14; Cytokeratin 16; cytokeratin-14; cytokeratin-16; Cytokeratin14; Cytokeratin16; epidermolysis bullosa simplex, Dowling-Meara, Koebner; focal non-epidermolytic palmoplantar keratoderma; K14; Keratin; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 16, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 16; keratin-14; keratin-16; KRT14; KRT16; KRT16A; Short name=CK-14; Short name=CK-16; Short name=K14; Short name=K16; type I cytoskeletal 14; type I cytoskeletal 16; type I keratin Ka14
AI324768; AI626930; CK14; CK16; EBS3; EBS4; FNEPPK; K14; K16; K1CP; Ka14; Krt-1.14; Krt1-14; Krt1-16; KRT14; KRT16; KRT16A; NEPPK; NFJ; PC1