PA5-16722 targets Cytokeratin 14 in immunohistochemistry (paraffin and Western blot applications and shows reactivity with Human samples.
The PA5-16722 immunogen is a synthetic peptide derived from C-terminal of human Keratin 14.
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CK-14; cytokeratin 14; Cytokeratin-14; Dowling-Meara; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; keratin; keratin 14 (epidermolysis bullosa simplex; keratin 14, type I; keratin complex 1, acidic, gene 14; Keratin, type I cytoskeletal 14; Keratin-14; Koebner); type I cytoskeletal 14
Gene Aliases: AI626930; CK14; EBS3; EBS4; K14; Krt-1.14; Krt1-14; KRT14; NFJ