This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
MA5-13730 targets Cytokeratin 16 in immunofluorescence and immunohistochemistry (paraffin) applications and shows reactivity with Human samples. Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes.
The MA5-13730 immunogen is a synthetic peptide from the C-terminus of human cytokeratin 16.
KRT16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CK-16; cytokeratin 16; Cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma; K16; keratin 16, type I; Keratin, type I cytoskeletal 16; Keratin-16
Gene Aliases: CK16; FNEPPK; K16; K1CP; KRT16; KRT16A; NEPPK; PC1
UniProt ID: (Human) P08779
Entrez Gene ID: (Human) 3868