|Tested species reactivity||Human|
|Published species reactivity||Non-human primate, Human, Mouse, Rhesus monkey|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human breast carcinoma cell line PMC-42.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody will not cross-react with porcine, mouse, rat, hamster, bovine, canine or sheep.
Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. Cytokeratin 18 belongs to type I family (acidic cytokeratins).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
MA1-19476 was used in immunohistochemistry to report on two cases of malignant transformation of adenomyoepithelioma of the breast by a monophasic population
|Marian C,Boila A,Soanca D,Malau M,Podeanu DM,Resetkova E,Stolnicu S||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (121:272)||2013|
Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas.
MA1-19476 was used in immunohistochemistry to study the value of KRT7 and WT1 expression profiles in differentiating Wilms' tumour, papillary renal cell tumour and mucinous tubular and spindle cell carcinoma precursor lesions
|Szponar A,Kovacs G||Virchows Archiv : an international journal of pathology (460:423)||2012|
Giant clear cell hidradenoma of the knee.
MA1-19476 was used in immunohistochemistry to report on a case of giant clear cell hidradenoma of the knee
|Yu G,Goodloe S,D'Angelis CA,McGrath BE,Chen F||Journal of cutaneous pathology (37:e37)||2010|
Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype.
MA1-19476 was used in immunohistochemistry to study 3D tumor spheroids enriched for a cancer stem cell phenotype
|Robertson FM,Ogasawara MA,Ye Z,Chu K,Pickei R,Debeb BG,Woodward WA,Hittelman WN,Cristofanilli M,Barsky SH||Journal of biomolecular screening (15:820)||2010|
|Non-human primate||Not Cited||
Endometrial profile of tamoxifen and low-dose estradiol combination therapy.
MA1-19476 was used in immunohistochemistry to detect effects of estradiol and tamoxifen on endometrial health
|Wood CE,Kaplan JR,Fontenot MB,Williams JK,Cline JM||Clinical cancer research : an official journal of the American Association for Cancer Research (16:946)||2010|
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.
MA1-19476 was used in immunohistochemistry to study malignant transformation in long-term cultures of bone marrow-derived human mesenchymal stem cells
|Røsland GV,Svendsen A,Torsvik A,Sobala E,McCormack E,Immervoll H,Mysliwietz J,Tonn JC,Goldbrunner R,Lønning PE,Bjerkvig R,Schichor C||Cancer research (69:5331)||2009|
Mammary gland development in early pubertal female macaques.
MA1-19476 was used in immunohistochemistry to investigate the effect of estradiol on early ductal and lobular development
|Wood CE,Hester JM,Cline JM||Toxicologic pathology (35:795)||2007|
An immunohistochemical profile of giant cell carcinoma of the larynx.
MA1-19476 was used in immunohistochemistry to report on a case of giant cell carcinoma of the larynx
|Gurbuz Y,Kose N,Aydin O,Ozturk M||Auris, nasus, larynx (34:413)||2007|
Cytokeratin expression in lichen amyloidosus and macular amyloidosis.
MA1-19476 was used in immunohistochemistry to investigate the expression of cytokeratins in lichen and macular amyloidosis and their diagnostic value
|Apaydin R,Gürbüz Y,Bayramgürler D,Müezzinoglu B,Bilen N||Journal of the European Academy of Dermatology and Venereology : JEADV (18:305)||2004|
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
MA1-19476 was used in immunoprecipitation to study the opposing effects of hyperglycemia and SIRT2 on keratin-8 lysine acetylation
|Snider NT,Leonard JM,Kwan R,Griggs NW,Rui L,Omary MB||The Journal of cell biology (200:241)||2013|
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates.
MA1-19476 was used in western blot to investigate the role of Notch and p63 in regulation of mammary epithelial cell fates
|Yalcin-Ozuysal O,Fiche M,Guitierrez M,Wagner KU,Raffoul W,Brisken C||Cell death and differentiation (17:1600)||2010|
Cytoskeletal keratin glycosylation protects epithelial tissue from injury.
MA1-19476 was used in western blot to study the role of cytoskeletal keratin glycosylation in protecting epithelial tissue from injury
|Ku NO,Toivola DM,Strnad P,Omary MB||Nature cell biology (12:876)||2010|
Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines.
MA1-19476 was used in western blot to study the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines
|Chang CY,Chiou PP,Chen WJ,Li YH,Yiu JC,Cheng YH,Chen SD,Lin CT,Lai YS||Research in veterinary science (88:285)||2010|
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.
MA1-19476 was used in western blot to study whether variants of keratin 8 and keratin 19 are associated with inflammatory bowel disease
|Tao GZ,Strnad P,Zhou Q,Kamal A,Zhang L,Madani ND,Kugathasan S,Brant SR,Cho JH,Omary MB,Duerr RH||Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (5:857)||2007|
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.
MA1-19476 was used in western blot to study the site-specific dephosphorylation of keratin 8 by protein phosphatase-2A and how this varies according to cell type
|Tao GZ,Toivola DM,Zhou Q,Strnad P,Xu B,Michie SA,Omary MB||Journal of cell science (119:1425)||2006|
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
MA1-19476 was used in western blot to study keratin 8 and keratin 18 hyperphosphorylation as markers for progression of human liver disease
|Toivola DM,Ku NO,Resurreccion EZ,Nelson DR,Wright TL,Omary MB||Hepatology (Baltimore, Md.) (40:459)||2004|
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.
MA1-19476 was used in western blot to study the role of keratin mutations in the predisposition to Fas-induced apoptosis and massive liver injury
|Ku NO,Soetikno RM,Omary MB||Hepatology (Baltimore, Md.) (37:1006)||2003|
Keratin 8 mutations in patients with cryptogenic liver disease.
MA1-19476 was used in western blot to study mutations of keratin 8 in cryptogenic liver disease patients
|Ku NO,Gish R,Wright TL,Omary MB||The New England journal of medicine (344:1580)||2001|
Directed differentiation of human embryonic stem cells to epidermal progenitors.
MA1-19476 was used in flow cytometry to discus a method for the differentiation of human embryonic stem cells into epidermal progenitors
|Metallo CM,Ji L,de Pablo JJ,Palecek SP||Methods in molecular biology (Clifton, N.J.) (585:83)||2009|
Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation.
MA1-19476 was used in ELISA to study epithelial cell caspase activation via detection of a durable keratin fragment
|Tao GZ,Li DH,Zhou Q,Toivola DM,Strnad P,Sandesara N,Cheung RC,Hong A,Omary MB||The Journal of pathology (215:164)||2008|