|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Semi-purified human cytokeratin preparation|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:25 - 50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13263 targets Cytokeratin 20 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The MA5-13263 immunogen is semi-purified human cytokeratin preparation.
Keratin 20/cytokeratin20 (CK20) is a Type-I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system. CK20 is also present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack in CK20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder.
MA5-13263 was used in immunohistochemistry - paraffin section to report a unique case of familial adenomatous polyposis
|Böger C,Haag J,Egberts JH,Röcken C||Pathology, research and practice (212:54)||2016|
|Not Applicable||Not Cited||
Increased utilization, verification, and clinical implications of immunocytochemistry: Experience in a northern New England hospital.
MA5-13263 was used in immunohistochemistry to study a northern New England hospital and increased utilization, verification, and clinical implications of immunocytochemistry
|Sauter JL,Ambaye AB,Mount SL||Diagnostic cytopathology (43:688)||2015|
Adenocarcinoma with sarcomatous dedifferentiation arising from mature cystic teratoma of the anterior mediastinum.
MA5-13263 was used in immunohistochemistry to report on a case of adenocarcinoma with sarcomatous dedifferentiation arising from mature cystic teratoma of the anterior mediastinum
|Kim JY,Lee CH,Park WY,Kim JY,Kim AR,Shin N,Park DY,Huh GY||Pathology, research and practice (208:741)||2012|
Primary mucinous cystadenoma of the spermatic cord within the inguinal canal.
MA5-13263 was used in immunohistochemistry to report on a case of primary mucinous cystadenoma of the spermatic cord
|Kim JY,Lee YT,Kang HJ,Lee CH||Diagnostic pathology (7:null)||2012|
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
MA5-13263 was used in immunohistochemistry to report on a case of miliary brain metastases from occult lung adenocarcinoma
|Kahveci R,Gürer B,Kaygusuz G,Sekerci Z||Journal of neurosciences in rural practice (3:386)||2012|
Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.
MA5-13263 was used in immunohistochemistry to evaluate Huntingtin-interacting protein 1 as a marker for Merkel cell carcinoma
|Ames HM,Bichakjian CK,Liu GY,Oravecz-Wilson KI,Fullen DR,Verhaegen ME,Johnson TM,Dlugosz AA,Ross TS||The Journal of investigative dermatology (131:2113)||2011|
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
MA5-13263 was used in immunohistochemistry to report on two cases of giant cell tumor-like lesion of the urinary bladder
|Behzato¿lu K,Durak H,Canberk S,Aydin O,Huq GE,Oznur M,Ozyalvaçli G,Yildiz P||Diagnostic pathology (4:null)||2009|
Tumourigenic effect of Schistosoma haematobium total antigen in mammalian cells.
MA5-13263 was used in immunohistochemistry to investigate the influence of S. haematobium total antigen on tumor development
|Botelho M,Oliveira P,Gomes J,Gartner F,Lopes C,da Costa JM,Machado JC||International journal of experimental pathology (90:448)||2009|
The presence of Merkel cells and CD10- and CD34-positive stromal cells compared in benign and malignant oral tumors.
MA5-13263 was used in immunohistochemistry to study the role of Merkel cells and CD10(+) and CD34(+) stromal cells in the transition from benign to malignant oral lesions
|Gao HW,Ho JY,Lee HS,Yu CP||Oral diseases (15:259)||2009|
Keratin profiling in the developing human prostate. A different approach to understanding epithelial lineage.
MA5-13263 was used in immunohistochemistry to investigate the distribution of keratin in prostate during development
|Trompetter M,Smedts F,van der Wijk J,Schoots C,de Jong HJ,Hopman A,de la Rosette J||Anticancer research (28:237)||2008|
Mucoepidermoid carcinoma of the parotid gland with ovarian and peritoneal metastasis.
MA5-13263 was used in immunohistochemistry to investigate the metastasis of mucoepidermoid carcinoma of the parotid gland
|Buyukkurt S,Altintas A,Gumurdulu D,Zeren H,Guzel B||The journal of obstetrics and gynaecology research (34:271)||2008|
Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma.
MA5-13263 was used in immunohistochemistry to report a clinical case of basaloid adenocarcinoma
|Marci V,Volante M,Cappia S,Righi L,Novello C,Scagliotti GV,Brambilla E,Papotti M||Virchows Archiv : an international journal of pathology (451:729)||2007|
Combination chemotherapy with gemcitabine and cisplatin as first-line treatment for immunohistochemically proven cholangiocarcinoma.
MA5-13263 was used in immunohistochemistry to investigate the combination chemotherapy of gemcitabine and cisplatin against cholangiocarcinoma
|Lee GW,Kang JH,Kim HG,Lee JS,Lee JS,Jang JS||American journal of clinical oncology (29:127)||2006|
Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients.
MA5-13263 was used in immunohistochemistry to study two adult patients with mesenchymal hamartoma of the liver
|Yesim G,Gupse T,Zafer U,Ahmet A||Journal of hepato-biliary-pancreatic surgery (12:502)||2005|
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
MA5-13263 was used in immunohistochemistry to investigate the diagnostic value of CDX-2 in lung metastases from colorectal carcinomas
|Barbareschi M,Murer B,Colby TV,Chilosi M,Macri E,Loda M,Doglioni C||The American journal of surgical pathology (27:141)||2003|
Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis.
MA5-13263 was used in immunohistochemistry - free floating to analyze the drive of Merkel cell production in postnatal, embryonic and adult mouse epidermis by ectopic Atoh1 expression
|Ostrowski SM,Wright MC,Bolock AM,Geng X,Maricich SM||Development (Cambridge, England) (142:2533)||2015|
Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells.
MA5-13263 was used in immunocytochemistry to study the rescue of colorectal cancer cells from senescence by the reconstitution of telomerase reverse transcriptase activity
|Dalerba P,Guiducci C,Poliani PL,Cifola I,Parenza M,Frattini M,Gallino G,Carnevali I,Di Giulio I,Andreola S,Lombardo C,Rivoltini L,Schweighoffer T,Belli F,Colombo MP,Parmiani G,Castelli C||Cancer research (65:2321)||2005|