Recommended positive controls: Skin.
Product requires high temperature antien unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
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Protein Aliases: 58 kDa cytokeratin; CK-5; CK-6A; CK-6D; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; Hom s 5; K5; K6A; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin K6h; keratin, epidermal type II, K6A; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin-5; Keratin-6A; keratin-6C; KRT6B; KRTL1; type-II keratin Kb12; Type-II keratin Kb5; Type-II keratin Kb6
Gene Aliases: CK-6C; CK-6E; CK5; CK6A; CK6C; CK6D; DDD; DDD1; EBS2; K5; K6A; K6C; K6D; KRT5; KRT5A; KRT6A; KRT6C; KRT6D; PC3