|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues on the C-term of human CK5|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 7 publications below|
MA5-14473 targets Cytokeratin 5 in IHC (P) applications and shows reactivity with Human samples.
The MA5-14473 immunogen is a synthetic peptide corresponding to residues on the C-term of human CK5.
Twenty human cytokeratins are divided into acidic (pI<5.7) and basic (pI>6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of cytokeratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of cytokeratins as markers in cancer research and tumor identification. Point mutations in cytokeratin-5 gene may cause Epidermolysis Bullosa Simplex and Dowling-Degos disease. cytokeratin-5 is expressed in most epithelioid and biphasic mesotheliomas, thymoma, squamous and other carcinomas. It is related to cytokeratin-6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems.
MA5-14473 was used in immunohistochemistry to examine the transcriptional regulation that dictates different bladder cancer subtypes.
|Eriksson P,Aine M,Veerla S,Liedberg F,Sjödahl G,Höglund M||BMC medical genomics (8:null)||2015|
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.
MA5-14473 was used in immunohistochemistry to investigate how DASC(p63/Krt5) regulates regeneration of tissue after influenza-induced lung damage.
|Zuo W,Zhang T,Wu DZ,Guan SP,Liew AA,Yamamoto Y,Wang X,Lim SJ,Vincent M,Lessard M,Crum CP,Xian W,McKeon F||Nature (517:616)||2015|
A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia.
MA5-14473 was used in immunohistochemistry to study the role of the cervical squamocolumnar junction in cervical remodeling and neoplasia
|Herfs M,Vargas SO,Yamamoto Y,Howitt BE,Nucci MR,Hornick JL,McKeon FD,Xian W,Crum CP||The Journal of pathology (229:460)||2013|
An immunohistochemical study of the origin of the solid strand in syringoma, using carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 5.
MA5-14473 was used in immunohistochemistry to study the precise cellular origin of syringoma
|Kim BC,Park EJ,Kwon IH,Cho HJ,Park HR,Kim KH,Kim KJ||International journal of dermatology (51:817)||2012|
A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.
MA5-14473 was used in immunohistochemistry to study the role of a discrete population of squamocolumnar junction cells in the pathogenesis of cervical cancer
|Herfs M,Yamamoto Y,Laury A,Wang X,Nucci MR,McLaughlin-Drubin ME,Münger K,Feldman S,McKeon FD,Xian W,Crum CP||Proceedings of the National Academy of Sciences of the United States of America (109:10516)||2012|
A molecular taxonomy for urothelial carcinoma.
MA5-14473 was used in immunohistochemistry to develop a molecular taxonomy for urothelial carcinoma
|Sjödahl G,Lauss M,Lövgren K,Chebil G,Gudjonsson S,Veerla S,Patschan O,Aine M,Fernö M,Ringnér M,Månsson W,Liedberg F,Lindgren D,Höglund M||Clinical cancer research : an official journal of the American Association for Cancer Research (18:3377)||2012|
Characterization of the expression of cytokeratins 5, 8, and 14 in mouse thymic epithelial cells during thymus regeneration following acute thymic involution.
MA5-14473 was used in immunohistochemistry to profile cytokeratin expression in murine thymic epithelial cells during thymus regeneration
|Lee EN,Park JK,Lee JR,Oh SO,Baek SY,Kim BS,Yoon S||Anatomy and cell biology (44:14)||2011|