MA5-12596 targets Cytokeratin 5 in IHC (P) applications and shows reactivity with Human samples.
The MA5-12596 immunogen is recombinant protein corresponding to C-terminal 103 aa of cytokeratin 5.
Twenty human keratins are divided into acidic (pI <5.7) and basic (pI >6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor identification. Point mutations in cytokeratin5 gene can cause various types of epidermolysis bullosa simplex. It is expressed in most epithelial and biphasic mesotheliomas.
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Protein Aliases: 58 kDa cytokeratin; CK-5; Cytokeratin-5; Dowling-Meara/Kobner/Weber-Cockayne types); epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin; keratin 5 (epidermolysis bullosa simplex; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin, type II cytoskeletal 5; Keratin-5; type II cytoskeletal 5; Type-II keratin Kb5
Gene Aliases: CK5; DDD; DDD1; EBS2; K5; KRT5; KRT5A
UniProt ID: (Human) P13647
Entrez Gene ID: (Human) 3852