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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Cytoskeleton preparation of HeLa Cells.|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between ~40 kDa and ~68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.
MA1-12591 was used in immunocytochemistry to study the role of human fibroblasts in inhibiting the growth of a xenograph model of proliferative breast disease
|Sadlonova A,Mukherjee S,Bowe DB,Gault SR,Dumas NA,Van Tine BA,Frolova N,Page GP,Welch DR,Novak L,Frost AR||The American journal of pathology (170:1064)||2007|
Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture.
MA1-12591 was used in immunocytochemistry to study the role of breast fibroblasts in modulating epithelial cell proliferation in three-dimensional in vitro co-culture
|Sadlonova A,Novak Z,Johnson MR,Bowe DB,Gault SR,Page GP,Thottassery JV,Welch DR,Frost AR||Breast cancer research : BCR (7:R46)||2005|
Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus.
MA1-12591 was used in immunohistochemistry to study the regulation of epithelial cell differentiation and human thymic medulla Hassall body formation by corticosteroids
|Hale LP,Markert ML||Journal of immunology (Baltimore, Md. : 1950) (172:617)||2004|
Sulfur mustard induces the formation of keratin aggregates in human epidermal keratinocytes.
MA1-12591 was used in western blot to study the effect of sulfur mustard on keratin biochemistry in human epidermal keratinocytes
|Dillman JF,McGary KL,Schlager JJ||Toxicology and applied pharmacology (193:228)||2003|
58 kda cytokeratin; CK-5; CK-8; CYK8; cytokeratin-5; cytokeratin-8; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 8, type II; Keratin type II cytoskeletal 5; Keratin type II cytoskeletal 8; KRT5; KRT8; type-II keratin Kb5; type-II keratin Kb8
CARD2; CK-8; CK5; CK8; CYK8; DDD; DDD1; EBS2; K2C8; K5; K8; KO; KRT5; KRT5A; KRT8