|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Human stratum corneum|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-34399 detects Cytokeratin 6 + 18 from human samples.
MA1-34399 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue), Western blot applications.
The MA1-34399 immunogen is: Human stratum corneum
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An unusual presentation of Helicobacter pylori infection: so-called "Russell body gastritis".
MA1-34399 was used in immunohistochemistry to report on a case of Helicobacter pylori infection with Russell body involvement
|Ensari A,Savas B,Okcu Heper A,Kuzu I,Idilman R||Virchows Archiv : an international journal of pathology (446:463)||2005|
Cytokeratin expression in lichen amyloidosus and macular amyloidosis.
MA1-34399 was used in immunohistochemistry to investigate the expression of cytokeratins in lichen and macular amyloidosis and their diagnostic value
|Apaydin R,Gürbüz Y,Bayramgürler D,Müezzinoglu B,Bilen N||Journal of the European Academy of Dermatology and Venereology : JEADV (18:305)||2004|
AC133-2, a novel isoform of human AC133 stem cell antigen.
MA1-34399 was used in immunocytochemistry to study a novel isoform of the human AC133 stem cell antigen
|Yu Y,Flint A,Dvorin EL,Bischoff J||The Journal of biological chemistry (277:20711)||2002|