|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 134 and 564 of Human Cytokeratin 6B|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29134 targets Cytokeratin 6B in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29134 immunogen is recombinant protein fragment corresponding to a region within amino acids 134 and 564 of Human Cytokeratin 6B.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CK-6B; CK6B; cytokeratin 6B; Cytokeratin-6B; epidermal; K6B; keratin; keratin 6B, type II; keratin complex 2, basic, gene 6b; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6B; keratin-6-beta; Keratin-6B; keratin-like 1 (a type II keratin sequence); KRTL1; mK6-beta; type II; type II cytoskeletal 6B; Type-II keratin Kb10
Gene Aliases: BB144589; CK-6B; CK6B; K6B; Krt2-6b; KRT6B; KRTL1; mK6[b]; PC2; PC4
UniProt ID: (Human) P04259
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