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|Tested species reactivity||Human|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgM|
|Immunogen||Cytoskeletal extract of human hepatocellular carcinoma cell line, Hep3B.|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-26896 detects Cytokeratin 8 from human samples.
MA1-26896 has been successfully used in immunohistochemistry (paraffin) procedures.
The MA1-26896 immunogen is cytoskeletal extract of human hepatocellular carcinoma cell line, Hep3B.
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes.
MA1-26896 was used in immunohistochemistry to study the ability to generate humanized rats with livers containing human hepatocytes using immunosuppressed infant animals treated with retrorsine
|Tachibana A,Tateno C,Yoshizato K||Xenotransplantation (20:227)||2013|
CARD2; CK8; CYK8; cytokeratin-8; K2C8; keratin 8, type II; KO; type-II keratin Kb8
CARD2; CK-8; CK8; CYK8; K2C8; K8; KO; KRT8