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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues of the human CK18|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14476 targets Cytokeratin 8 in IHC (P) applications and shows reactivity with Human samples.
The MA5-14476 immunogen is a synthetic peptide corresponding to residues of the human CK18.
Cytokeratin 8 belongs to the type B (basic) subfamily of low molecular weight keratins and usually exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non-squamous simple epithelia. It is expressed in mesothelioma and most adenocarcinomas of simple epithelium including breast ducts, gall bladder, intestine, liver, pancreas and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
MA5-14476 was used in immunocytochemistry and western blot to study the opposing effects of hyperglycemia and SIRT2 on keratin-8 lysine acetylation
|Snider NT,Leonard JM,Kwan R,Griggs NW,Rui L,Omary MB||The Journal of cell biology (200:241)||2013|
Characterization of the expression of cytokeratins 5, 8, and 14 in mouse thymic epithelial cells during thymus regeneration following acute thymic involution.
MA5-14476 was used in immunohistochemistry to profile cytokeratin expression in murine thymic epithelial cells during thymus regeneration
|Lee EN,Park JK,Lee JR,Oh SO,Baek SY,Kim BS,Yoon S||Anatomy & cell biology (44:14)||2011|
CK-8; cytokeratin 8; cytokeratin-8; keratin; keratin 8, type II; keratin-8; type II cytoskeletal 8; type-II keratin Kb8
CARD2; CK-8; CK8; CYK8; K2C8; K8; KO; KRT8