This Antibody was verified by KnockOut to ensure that the antibody binds to the antigen stated. View Details
PA5-29607 targets Cytokeratin 8 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29607 immunogen is recombinant fragment corresponding to a region within amino acids 49 and 301 of Human Cytokeratin 8.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
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Protein Aliases: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin endo A; Cytokeratin-8; K2C8; K8; keratin; keratin 8, type II; keratin complex 2, basic, gene 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; type II cytoskeletal 8; Type-II keratin Kb8
Gene Aliases: AA960620; AL022697; AU019895; CARD2; CK-8; CK8; CYK8; EndoA; K2C8; K8; KO; Krt-2.8; Krt2-8; KRT8