Search

  • Order Status
  • Quick Order
  • Promos

NeoBiotechnologies

Cytokeratin, Multi (Epithelial Marker) Monoclonal Antibody (KRT/457)

View all (73) Cytokeratin Pan Type I/II antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Cytokeratin, Multi (Epithelial Marker) Monoclonal Antibody (KRT/457)

Product Details

MSM15-457-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-
Product Specifications

Species Reactivity

Amphibian, Bovine, Guinea pig, Goat, Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

KRT/457

Immunogen

Keratin-enriched preparation from cultured human epithelial cells
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK 2e; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; cytoskeletal protein; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein; intermediate filament protein K16; intermediate filament protein; K7; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; KERA; keratin 1, type II; keratin 10; keratin 10 (epidermolytic hyperkeratosis); keratin 10, type I; keratin 13, type I; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17; keratin 17, type I; keratin 18, type I; keratin 19; keratin 19, type I; Keratin 1B; keratin 2 (epidermal ichthyosis bullosa of Siemens); keratin 2 epidermis; keratin 2, type II; keratin 2A; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 7, type II; keratin 76, type II; keratin 77; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin IV; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 59 kDa, component IV; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; Keratin-7; Keratin-76; Keratin-77; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt10 {ECO:0000250|UniProtKB:P13645}; krt13 {ECO:0000250|UniProtKB:P13646}; krt15 {ECO:0000250|UniProtKB:P19012}; krt17 {ECO:0000250|UniProtKB:Q04695}; krt18 {ECO:0000250|UniProtKB:P05783}; KRT1B; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; KRT5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; mK6-alpha; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; Type I keratin Ka10; Type I keratin Ka13; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka17; Type I keratin Ka19; type II cytokeratin A (no.8); type II cytoskeletal 1b; type II keratin Kb1; type II keratin Kb2; type II keratin Kb39; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; unnamed protein product

View more View less

Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AEI2; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb7; Kb9; Ker2; Kerd; KERIA; KERIB; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; Krt6b; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; MECD2; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; Sak57; SCL; Tfip8; WSN1; WSN2

View more View less

UniProt ID: (Human) P04264, (Bovine) P06394, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Bovine) A1L595, (Human) P05783, (Bovine) P08728, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Bovine) Q5XQN5, (Human) P02538, (Bovine) Q29S21, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Bovine) P05786, (Human) P05787, (Mouse) P04104, (Rat) Q6IMF3, (Mouse) P02535, (Rat) Q6IFW6, (Mouse) P08730, (Rat) Q6IFV4, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Mouse) Q3TTY5, (Rat) Q6IG02, (Rat) Q6IG00, (Mouse) P07744, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Rat) Q6IG12, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Mouse) Q6IFZ6, (Rat) Q6IG01, (Rat) Q10758, (Mouse) P11679

View more View less

Entrez Gene ID: (Pig) 100049664, (Human) 3848, (Goat) 102175951, (Bovine) 281888, (Goat) 102168294, (Pig) 100519971, (Human) 3858, (Human) 3860, (Goat) 102178106, (Bovine) 404111, (Human) 3861, (Pig) 100515506, (Bovine) 507464, (Human) 3866, (Human) 3868, (Human) 3872, (Bovine) 281889, (Bovine) 506480, (Pig) 100126286, (Goat) 102181566, (Human) 3875, (Bovine) 514812, (Pig) 100515339, (Human) 3880, (Goat) 106501743, (Pig) 100049665, (Goat) 102176227, (Human) 3849, (Bovine) 407188, (Pig) 100157304, (Goat) 102182381, (Human) 3850, (Bovine) 527819, (Human) 3851, (Goat) 102183210, (Pig) 100157675, (Human) 3852, (Goat) 102175207, (Pig) 100511564, (Bovine) 281268, (Human) 3853, (Pig) 102164968, (Goat) 102174931, (Bovine) 614456, (Bovine) 535697, (Human) 3855, (Goat) 102184596, (Bovine) 407189, (Human) 51350, (Goat) 102175675, (Pig) 100156059, (Human) 374454, (Pig) 100152077, (Bovine) 281269, (Goat) 102182762, (Human) 3856, (Guinea pig) 100714242, (Mouse) 16678, (Rat) 300250, (Mouse) 16661, (Rat) 450225, (Mouse) 16663, (Guinea pig) 100713183, (Rat) 287699, (Mouse) 16664, (Rat) 287701, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Guinea pig) 100735962, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Guinea pig) 100714514, (Mouse) 16681, (Rat) 406228, (Guinea pig) 100713688, (Guinea pig) 100729006, (Rat) 315323, (Mouse) 16682, (Guinea pig) 100715346, (Rat) 369017, (Mouse) 110308, (Guinea pig) 100715629, (Mouse) 16687, (Rat) 300242, (Guinea pig) 100715259, (Mouse) 110310, (Rat) 407757, (Mouse) 77055, (Mouse) 406220, (Rat) 406226, (Rat) 25626, (Guinea pig) 100736243, (Mouse) 16691, (Guinea pig) 100712996, (Guinea pig) 100713272, (Guinea pig) 100713456, (Guinea pig) 100713547, (Guinea pig) 100713966, (Guinea pig) 100732091

View more View less

Function(s)
protein binding carbohydrate binding structural constituent of epidermis signaling receptor activity protein heterodimerization activity structural molecule activity structural constituent of cytoskeleton keratin filament binding scaffold protein binding RNA binding cadherin binding involved in cell-cell adhesion structural constituent of muscle macromolecular complex binding cytoskeletal protein binding molecular_function MHC class II receptor activity MHC class II protein binding poly(A) RNA binding protein complex binding
Process(es)
cytoskeleton organization Notch signaling pathway response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development positive regulation of epidermis development protein heterotetramerization aging epithelial cell differentiation hair cycle intermediate filament bundle assembly morphogenesis of an epithelium positive regulation of cell proliferation cell differentiation keratinization killing of cells of other organism wound healing intermediate filament organization defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of entry of bacterium into host cell biological_process intermediate filament-based process positive regulation of cell growth hair follicle morphogenesis positive regulation of translation positive regulation of hair follicle development cellular response to calcium ion inflammatory response keratinocyte differentiation negative regulation of cell migration innate immune response intermediate filament cytoskeleton organization keratinocyte migration establishment of skin barrier negative regulation of epithelial cell proliferation complement activation, lectin pathway negative regulation of inflammatory response tumor necrosis factor-mediated signaling pathway response to hydrostatic pressure response to other organism extrinsic apoptotic signaling pathway hepatocyte apoptotic process epidermis development Wnt signaling pathway response to mechanical stimulus regulation of cell migration regulation of protein localization intermediate filament polymerization response to oxidative stress peptide cross-linking fibrinolysis regulation of angiogenesis signal transduction regulation of translation in response to stress response to zinc ion response to ionizing radiation retina homeostasis Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process response to radiation stem cell differentiation anatomical structure morphogenesis Golgi to plasma membrane protein transport cell-cell adhesion mitophagy in response to mitochondrial depolarization tongue morphogenesis cellular response to retinoic acid embryo development sebaceous gland development keratinocyte activation keratinocyte proliferation immune system process cell morphogenesis involved in differentiation multicellular organism development pigmentation keratinocyte development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support