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D4 Dopamine Receptor Antibody (PA5-28756) in IHC (F)
Dopamine receptor D4 antibody detects dopamine receptor D4 protein on embryonic mouse brain by immunohistochemical analysis. Sample: Frozen section of embryonic mouse brain (mE18.5). Red: dopamine receptor D4 antibody [N1] [ (Product # PA5-28756)] diluted at 1:250. Blue: DAPI.
Product Details
PA5-28756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human dopamine receptor D4
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546232
Product Specific Information
Recommended positive controls: HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor
Gene Aliases: AW125663; D4DR; D4R; Drd-4; DRD4
UniProt ID: (Human) P21917, (Mouse) P51436
Entrez Gene ID: (Human) 1815, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gs
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity
protein binding
drug binding
potassium channel regulator activity
SH3 domain binding
dopamine binding
identical protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
activation of MAPK activity
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
cellular calcium ion homeostasis
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
short-term memory
circadian rhythm
adult locomotory behavior
olfactory learning
photoperiodism
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
response to histamine
social behavior
regulation of dopamine metabolic process
dopamine metabolic process
fear response
regulation of circadian rhythm
regulation of neurotransmitter secretion
behavioral response to cocaine
behavioral response to ethanol
response to steroid hormone
arachidonic acid secretion
negative regulation of protein secretion
regulation of calcium-mediated signaling
positive regulation of dopamine uptake involved in synaptic transmission
retina development in camera-type eye
inhibitory postsynaptic potential
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
signal transduction
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
associative learning
rhythmic process
modulation of synaptic transmission
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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