Invitrogen

D4 Dopamine Receptor Monoclonal Antibody (625CT1.5.4)

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D4 Dopamine Receptor Antibody in Western Blot (WB) — Western Blot analysis of D4 Dopamine Receptor using the D4 Dopamine Receptor Monoclonal Antibody (Product # MA5-37614) in mouse heart tissue lysates (35 µg/lane).

Product Details

MA5-37614

Applications	Tested Dilution	Publications
Western Blot (WB)	1:100-1:250	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	625CT1.5.4
Immunogen	KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	Lot-Specific
Purification	Protein G
Storage buffer	PBS
Contains	0.09% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target Information

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor

Gene Aliases: AW125663; D4DR; D4R; Drd-4; DRD4

UniProt ID: (Human) P21917, (Mouse) P51436

Entrez Gene ID: (Human) 1815, (Mouse) 13491

Molecular Function: G-protein coupled receptor

activation of MAPK activity behavioral fear response synaptic transmission, dopaminergic response to amphetamine cellular calcium ion homeostasis negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway short-term memory circadian rhythm adult locomotory behavior olfactory learning photoperiodism negative regulation of cAMP biosynthetic process positive regulation of sodium:proton antiporter activity positive regulation of kinase activity response to histamine social behavior regulation of dopamine metabolic process dopamine metabolic process fear response regulation of circadian rhythm regulation of neurotransmitter secretion behavioral response to cocaine behavioral response to ethanol response to steroid hormone arachidonic acid secretion negative regulation of protein secretion regulation of calcium-mediated signaling positive regulation of dopamine uptake involved in synaptic transmission retina development in camera-type eye inhibitory postsynaptic potential positive regulation of penile erection negative regulation of voltage-gated calcium channel activity positive regulation of excitatory postsynaptic potential signal transduction G-protein coupled receptor signaling pathway chemical synaptic transmission sensory perception of chemical stimulus associative learning rhythmic process modulation of synaptic transmission

Process(es)

dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine neurotransmitter receptor activity protein binding drug binding potassium channel regulator activity SH3 domain binding dopamine binding identical protein binding signal transducer activity G-protein coupled receptor activity G-protein coupled amine receptor activity