This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
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Protein Aliases: AOC1; D-amino-acid oxidase; DAAO; Diamine oxidase
Gene Aliases: DAAO; DAMOX; DAO; OXDA
UniProt ID: (Human) P14920
Entrez Gene ID: (Human) 1610