CDK5RAP2 is a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein is localized to the centrosome and Golgi complex and interacts with CDK5R1 and pericentrin (PCNT). CDK5RAP2 plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
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Protein Aliases: aging-associated protein 1; DAP-5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; Novel APOBEC-1 target 1; p97; Translation repressor NAT1
Gene Aliases: AA589388; AAG1; DAP-5; DAP5; E130105L11Rik; EIF4G2; NAT1; Natm1; OK/SW-cl.75; P97