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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||His6-tagged protein corresponding to amino acids 580-740 of human Daxx.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BING2; CENP-C binding protein; DADB-159G18.9; DAP6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; fas death domain-associated protein; Fas-binding protein; MGC126245; MGC126246
BING2; DAP6; DAXX; EAP1