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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Extracellular domain of the human DCC protein. DCC, p190, has been identified as the netrin-1 receptor.|
|Storage buffer||0.05M sodium phosphate with 0.25% gelatin|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||1-5 ug/ml|
|Immunofluorescence (IF)||1-5 µg/ml|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25883 detects DCC from human samples.
MA1-25883 has been successfully used in immunoprecipitation, immunofluorescence, and Western blot procedures.
The MA1-25883 immunogen is the extracellular domain of the human DCC protein. DCC, p190, has been identified as the netrin-1 receptor.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; netrin receptor DCC; tumor suppressor protein DCC
CRC18; CRCR1; IGDCC1; MRMV1
Signal transduction Cell communication Ligand-mediated signaling Oncogenesis Developmental processes Ectoderm development Neurogenesis Apoptosis Induction of apoptosis Cell structure and motility Cell motility Cell proliferation and differentiation Cell adhesion