Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product # 7KMWCO
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
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Protein Aliases: Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; deleted in colorectal cancer protein; deleted in colorectal carcinoma; HGPPS2; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; Tumor suppressor protein DCC
Gene Aliases: CRC18; CRCR1; DCC; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146
Entrez Gene ID: (Human) 1630
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor