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Invitrogen
DCC Recombinant Rabbit Monoclonal Antibody (PSH12-73)
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Product Details
MA569997
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH12-73
Immunogen
Recombinant protein within human DCC aa 1-1097.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Mouse brain (P0) tissue lysate, Mouse brain (P7) tissue lysate, Rat brain tissue lysate.
Subcellular location: Membrane.
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; Netrin receptor DCC; putative colorectal tumor suppressor; Tumor suppressor protein DCC
Gene Aliases: C030036D22Rik; CRC18; CRCR1; DCC; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146, (Mouse) P70211, (Rat) Q63155
Entrez Gene ID: (Human) 1630, (Mouse) 13176, (Rat) 25311
neuron migration
apoptotic process
axonogenesis
axon guidance
negative regulation of neuron projection development
spinal cord ventral commissure morphogenesis
dorsal/ventral axon guidance
anterior/posterior axon guidance
netrin-activated signaling pathway
negative regulation of collateral sprouting
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neuron death
negative regulation of dendrite development
multicellular organism development
positive regulation of neuron projection development
positive regulation of ERK1 and ERK2 cascade
regulation of nucleic acid-templated transcription
response to amphetamine
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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