Sequence of this protein is as follows: RTAENKLDTK YPYVCHAELN AIMNKNSTDV KGCSMYVALF PCNECAKLII QAGIKEVIFM SDKYHDSDEA TAARLLFNMA GVTFRKFIPK CSKIVIDFDS INSRPSQKLQ
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
Protein Aliases: dCMP deaminase; Deoxycytidylate deaminase
Gene Aliases: DCTD
UniProt ID: (Human) P32321
Entrez Gene ID: (Human) 1635