This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation end products (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: advanced glycation end-product receptor 1; advanced glycation endproduct receptor 1; AGE-R1; DDOST 48 kDa subunit; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic); dolichyl-diphosphooligosaccharide-protein glycotransferase; MGC2191; oligosaccharyl transferase 48 kDa subunit; oligosaccharyltransferase 48 kDa subunit; oligosaccharyltransferase subunit 48
Gene Aliases: AGER1; CDG1R; DDOST; KIAA0115; OK/SW-cl.45; OKSWcl45; OST; OST48; WBP1
UniProt ID: (Human) P39656
Entrez Gene ID: (Human) 1650
Molecular Function: glycosyltransferase