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FIGURE: 1 / 1
DEK Antibody (CL647-66194) in Flow
1X10^6 K-562 cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human DEK (CL647-66194, Clone:5E3A6) (red), or 0.2 µg isotype control (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL647-66194
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5E3A6
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT ERKDFIKTTV KELIS
Target Information
DEK is a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DEK oncogene (DNA binding); Protein DEK
Gene Aliases: 1810019E15Rik; D13H6S231E; D6S231E; DEK
UniProt ID: (Human) P35659, (Rat) Q6AXS3, (Mouse) Q7TNV0
Entrez Gene ID: (Human) 7913, (Rat) 306817, (Mouse) 110052
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
signal transduction
covalent chromatin modification
viral genome replication
positive regulation of gene expression, epigenetic
regulation of double-strand break repair
regulation of double-strand break repair via nonhomologous end joining
biological_process
chromatin modification
cell quiescence
Performance Guarantee
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