Immunogen sequence: PSGIFDVNSR KSSTGSISNV LFSTQDPVED AVFGEATNLK KNGDRGEKRQ KHFPERSCSF SSESRAGMLL KKSSLDSNSS EMAIMMGADA KILTAALTCP KTSLLHIART HSFENVSCHL PDSRTCMSES TW
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 86%.
DENND4C is guanine nucleotide exchange factor (GEF) activating RAB10. It promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DENN domain-containing protein 4C; DENN/MADD domain containing 4A pseudogene; DENN/MADD domain containing 4C; likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)
Gene Aliases: 1700065A05Rik; AA420392; bA513M16.3; C9orf55; C9orf55B; DENND4C; RAB10GEF; RGD1308489