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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 3 publications 3 publications |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
4D11A3 |
Immunogen |
DGCR8 Fusion Protein Ag4871 (167-517 aa encoded by BC009323) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: VKAKVEVCK DESVDLEEFR SYLEKRFDFE QVTVKKFRTW AERRQFNREM KRKQAESERP ILPANQKLIT LSVQDAPTKK EFVINPNGKS EVCILHEYMQ RVLKVRPVYN FFECENPSEP FGASVTIDGV TYGSGTASSK KLAKNKAARA TLEILIPDFV KQTSEEKPKD SEELEYFNHI SIEDSRVYEL TSKAGLLSPY QILHECLKRN HGMGDTSIKF EVVPGKNQKS EYVMACGKHT VRGWCKNKRV GKQLASQKIL QLLHPHVKNW GSLLRMYGRE SSKMVKQETS DKSVIELQQY AKKNKPNLHI LSKLQEEMKR LAEEREETRK KPKMSIVASA QPGGEPLCTV DV (167-517 aa encoded by BC009323)
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DiGeorge syndrome critical region 8; DiGeorge syndrome critical region 8 homolog; DiGeorge syndrome critical region gene 8; Gy1; Microprocessor complex subunit DGCR8
Gene Aliases: C22orf12; D16H22S1742E; D16H22S788E; D16Wis2; DGCR8; DGCRK6; Gy1; LP4941; mir-1306; N41; pasha; Vo59c07
UniProt ID: (Human) Q8WYQ5, (Mouse) Q9EQM6
Entrez Gene ID: (Human) 54487, (Mouse) 94223, (Rat) 287954
Molecular Function:
RNA metabolism protein
RNA processing factor
nucleic acid metabolism protein
scaffold/adaptor protein
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