Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, and is required for the synthesis of purines, thymidylic acid and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
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Protein Aliases: Dihydrofolate reductase
Gene Aliases: DHFR; DHFRP1; DYR
UniProt ID: (Human) P00374
Molecular Function: reductase