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Invitrogen

DJ-1 Recombinant Rabbit Monoclonal Antibody (007)

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DJ-1 Recombinant Rabbit Monoclonal Antibody (007)

Product Details

MA5-29462

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:20-1:100
-

Flow Cytometry (Flow)

1:25-1:100
-

Immunoprecipitation (IP)

1-4 µL/mg of lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

007

Immunogen

Recombinant Human PARK7/DJ-1 protein (Met1-Asp189)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2785323

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Human PARK7/DJ-1.

Target Information

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CTA-215D11.1; DJ-1; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; parkinson protein 7; Parkinsonism-associated deglycase; protein deglycase DJ-1; Protein DJ-1; Protein/nucleic acid deglycase DJ-1; unnamed protein product

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Gene Aliases: DJ-1; DJ1; GATD2; HEL-S-67p; PARK7

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UniProt ID: (Human) Q99497

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Entrez Gene ID: (Human) 11315

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Function(s)
core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor hydrolase activity oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity
Process(es)
synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus DNA repair proteolysis autophagy inflammatory response cellular response to DNA damage stimulus response to oxidative stress mitochondrion organization Ras protein signal transduction single fertilization adult locomotory behavior methylglyoxal metabolic process detoxification of copper ion positive regulation of gene expression negative regulation of gene expression lactate biosynthetic process removal of superoxide radicals insulin secretion protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of TRAIL production positive regulation of interleukin-8 production negative regulation of protein sumoylation cellular response to oxidative stress cellular response to reactive oxygen species cellular response to glyoxal negative regulation of protein catabolic process response to hydrogen peroxide glucose homeostasis hydrogen peroxide metabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide methylglyoxal catabolic process to lactate cellular response to hydrogen peroxide detection of oxidative stress guanine deglycation guanine deglycation, methylglyoxal removal guanine deglycation, glyoxal removal cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of fibril organization positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process positive regulation of L-dopa biosynthetic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process positive regulation of mitophagy negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway
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