Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Mutations in the PARK7/DJ-1 gene cause autosomal-recessive Parkinsons disease.
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Protein Aliases: Contraception-associated protein 1; DJ-1; epididymis secretory sperm binding protein Li 67p; Fertility protein SP22; Maillard deglycase; Oncogene DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Parkinson disease protein 7 homolog; parkinson protein 7; Parkinsonism-associated deglycase; Protein CAP1; Protein deglycase DJ-1; Protein DJ-1; Protein/nucleic acid deglycase DJ-1; RNA-binding protein regulatory subunit
Gene Aliases: CAP1; DJ-1; DJ1; HEL-S-67p; PARK7; SP22