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DLX2 Antibody (MA5-47229) in ICC/IF
Immunofluorescent analysis of DLX2 in DIV9 rat E18 primary cortical neuron and glia cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: DLX2 stained by DLX2 monoclonal antibody (Product # MA5-47229) diluted at 1:250. Red: Tau, an axon marker, stained by Tau antibody [GT287] diluted at 1:500. Blue: Fluoroshield with DAPI.
Product Details
MA5-47229
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
HL1942
Immunogen
Recombinant fragment of human DLX2
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: distal-less homeo box 2; DLX-5; homeobox Dlx5; Homeobox protein DLX-2
Gene Aliases: DLX2; Dlx5; TES-1; TES1
UniProt ID: (Human) Q07687
Entrez Gene ID: (Human) 1746, (Rat) 296499
Molecular Function:
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
brain development
proximal/distal pattern formation
subpallium development
hippocampus development
olfactory bulb development
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
cerebral cortex GABAergic interneuron fate commitment
odontogenesis of dentin-containing tooth
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
negative regulation of oligodendrocyte differentiation
branching morphogenesis of a nerve
cartilage development
regulation of transcription from RNA polymerase II promoter
forebrain neuron differentiation
cerebral cortex GABAergic interneuron differentiation
cell differentiation
embryonic skeletal system development
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
single-stranded RNA binding
protein binding
DNA binding
sequence-specific DNA binding
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