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DMRT1 Antibody (TA807517) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DMRT1 (RC208108, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DMRT1. Positive lysates LY411862 (100 µg) and LC411862 (20 µg) can be purchased separately from OriGene.
Product Details
TA807517
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1G10
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-210 of human DMRT1 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DM domain expressed in testis 1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
Gene Aliases: CT154; DMRT1; DMT1
UniProt ID: (Human) Q9Y5R6
Entrez Gene ID: (Human) 1761
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
male germ cell proliferation
transcription from RNA polymerase II promoter
spermatogenesis
sex differentiation
germ cell migration
male sex determination
intracellular signal transduction
negative regulation of meiotic nuclear division
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
male sex differentiation
oocyte development
Sertoli cell differentiation
Sertoli cell development
positive regulation of meiosis I
regulation of nodal signaling pathway
positive regulation of male gonad development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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