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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Full-length recombinant human DNA Ligase I protein|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-23187 detects DNA ligase I in Human samples.
PA1-23187 has been successfully used in Western Blot procedures.
Positive Control: HeLa
PA1-23187 immunogen corresponds to Full-length recombinant human DNA Ligase I protein.
There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase I migrates as a 125kDa phosphoprotein and is implicated in joining Okazaki fragments during DNA synthesis. It also has a role in the base and nucleotide excision repair pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA ligase 1; DNA ligase I; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1