This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (92%), Rat (91%), Pig (94%), Rhesus Monkey (97%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III gene product migrates as a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed and complexes with XRCC-1 and a 97 kDa (beta form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in the base excision repair pathway.
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Protein Aliases: DNA ligase 3; DNA ligase III; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 3
Gene Aliases: LIG2; LIG3
UniProt ID: (Human) P49916
Entrez Gene ID: (Human) 3980