Product References
Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.
Targeted oncology
Huguet F,Fernet M,Giocanti N,Favaudon V,Larsen AK
MA513244 was used in western blot to investigate the in vitro anti-tumor activity of afatinib.
Wed Jun 01 00:00:00 EDT 2016
p21 promotes error-free replication-coupled DNA double-strand break repair.
Nucleic acids research
Mauro M,Rego MA,Boisvert RA,Esashi F,Cavallo F,Jasin M,Howlett NG
MA5-13244 was used in western blot to study the role of p21 in error-free replication-coupled DNA double-strand break repair.
Sat Sep 01 00:00:00 EDT 2012
Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair.
International journal of radiation oncology, biology, physics
Kang KB,Zhu C,Wong YL,Gao Q,Ty A,Wong MC
MA5-13244 was used in western blot to study the molecular mechanism by which gefitinib radiosensitizes brain tumor stem cells
Tue May 01 00:00:00 EDT 2012
Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit.
International journal of radiation oncology, biology, physics
Xiong H,Lee RJ,Haura EB,Edwards JG,Dynan WS,Li S
MA5-13244 was used in immunocytochemistry to develop a system for the intra-nuclear delivery of a radiosensitizer based on a single-chain antibody fragment targeting the catalytic subunit of DNA-PK
Sun Jul 01 00:00:00 EDT 2012
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Journal of virology
Vogel R,Seyffert M,Strasser R,de Oliveira AP,Dresch C,Glauser DL,Jolinon N,Salvetti A,Weitzman MD,Ackermann M,Fraefel C
MA5-13244 was used in flow cytometry, immunocytochemistry, and western blot to study the characteristics of the DNA damage response induced by co-infection with AAV2 and HSV-1
Sun Jan 01 00:00:00 EST 2012
Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia.
British journal of haematology
Elliott SL,Crawford C,Mulligan E,Summerfield G,Newton P,Wallis J,Mainou-Fowler T,Evans P,Bedwell C,Durkacz BW,Willmore E
MA5-13244 was used in western blot to evaluate a combination therapy for B-cell chronic lymphocytic leukaemia
Sat Jan 01 00:00:00 EST 2011
The Ku-dependent non-homologous end-joining pathway contributes to low-dose radiation-stimulated cell survival.
Journal of cellular physiology
Yu X,Wang H,Wang P,Chen BP,Wang Y
MA5-13244 was used in western blot to study low-dose radiation induction of cell survival and the mechanistic role of Ku-dependent non-homologous end joining
Tue Feb 01 00:00:00 EST 2011
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.
The EMBO journal
Bombarde O,Boby C,Gomez D,Frit P,Giraud-Panis MJ,Gilson E,Salles B,Calsou P
MA5-13244 was used in immunoprecipitation to investigate the role of TRF2/RAP1 and DNA-PK at telomeric fusion
Wed May 05 00:00:00 EDT 2010
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Genes & development
Takai H,Xie Y,de Lange T,Pavletich NP
MA5-13244 was used in western blot to study the role of Tel2 in the Hsp90-dependent maturation of mTOR and ATR complexes
Wed Sep 15 00:00:00 EDT 2010
Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair.
Cell cycle (Georgetown, Tex.)
Velkova A,Carvalho MA,Johnson JO,Tavtigian SV,Monteiro AN
MA5-13244 was used in western blot to study the interaction between the BRCA protein and filamin A and its role in efficient DNA repair
Thu Apr 01 00:00:00 EDT 2010
Defective Artemis causes mild telomere dysfunction.
Genome integrity
Yasaei H,Slijepcevic P
MA5-13244 was used in western blot to study the role of defective Artemis in telomere dysfunction
Wed May 26 00:00:00 EDT 2010
The effect of DNA-dependent protein kinase on adeno-associated virus replication.
PloS one
Choi YK,Nash K,Byrne BJ,Muzyczka N,Song S
MA5-13244 was used in blocking or activating experiment to study the role of DNA-dependent protein kinase in adeno-associated virus replication
Mon Dec 20 00:00:00 EST 2010
Adeno-associated virus site-specific integration is mediated by proteins of the nonhomologous end-joining pathway.
Journal of virology
Daya S,Cortez N,Berns KI
MA5-13244 was used in immunoprecipitation to study the mechanism of adeno-associated virus site-specific integration
Sun Nov 01 00:00:00 EDT 2009
DNA-dependent protein kinase is a novel interaction partner for Ets-1 isoforms.
Biochemical and biophysical research communications
Choul-li S,Drobecq H,Aumercier M
MA5-13244 was used in western blot to study the interaction of DNA-PK with the Ets-1 transcription factor
Fri Dec 18 00:00:00 EST 2009
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
Willmore E,Elliott SL,Mainou-Fowler T,Summerfield GP,Jackson GH,O'Neill F,Lowe C,Carter A,Harris R,Pettitt AR,Cano-Soumillac C,Griffin RJ,Cowell IG,Austin CA,Durkacz BW
MA5-13244 was used in western blot to examine the prognostic and therapeutic significance of DNA-dependent protein kinase in B-cell chronic lymphocytic leukemia
Sun Jun 15 00:00:00 EDT 2008
Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseases.
Rheumatology (Oxford, England)
Schild-Poulter C,Su A,Shih A,Kelly OP,Fritzler MJ,Goldstein R,Haché RJ
MA5-13244 was used in ChIP assay to study autoantibodies to Ku and DNA repair proteins in connective tissue diseases
Fri Feb 01 00:00:00 EST 2008
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Biochemistry
Zhong X,Safa AR
MA5-13244 was used in western blot to study the role of RNA helicase A phosphorylation in the expression of P-glycoprotein in multidrug-resistant human leukemia cells
Tue May 15 00:00:00 EDT 2007
DNA end joining activity is reduced in Alzheimer's disease.
Neurobiology of aging
Shackelford DA
MA5-13244 was used in western blot to study the role of DNA-dependent protein kinase in reduced DNA end joining activity in Alzheimer's disease
Sat Apr 01 00:00:00 EST 2006
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
Nature cell biology
Lau A,Swinbank KM,Ahmed PS,Taylor DL,Jackson SP,Smith GC,O'Connor MJ
MA5-13244 was used in western blot to study the role of a small molecule inhibitor of ATM kinase in suppressing HIV-1 infection
Sun May 01 00:00:00 EDT 2005
The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.
The Journal of experimental medicine
Poinsignon C,Moshous D,Callebaut I,de Chasseval R,Villey I,de Villartay JP
MA5-13244 was used in western blot to study the role of the metallo-beta-lactamase/beta-CASP domain of Artemis as the catalytic core for V(D)J recombination
Mon Feb 02 00:00:00 EST 2004
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Proceedings of the National Academy of Sciences of the United States of America
Song S,Lu Y,Choi YK,Han Y,Tang Q,Zhao G,Berns KI,Flotte TR
MA5-13244 was used in western blot to study the inhibitory effect of DNA-PK on adeno-associated virus integration in mouse liver in vitro and in vivo
Tue Feb 17 00:00:00 EST 2004
Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis.
Oncogene
Loong SL,Korzh S,Price A
MA5-13244 was used in western blot to study the reduced DNA-PK activity of two immortalized lymphoblastoid cell lines from adult cancer patients suffering late radionecrosis and the significance for radionecrosis susceptibility
Thu Jul 15 00:00:00 EDT 2004
Backup pathways of NHEJ are suppressed by DNA-PK.
Journal of cellular biochemistry
Perrault R,Wang H,Wang M,Rosidi B,Iliakis G
MA5-13244 was used in western blot to study the suppression of alternative, backup pathways of non-homolgous end joining by DNA-PK
Thu Jul 01 00:00:00 EDT 2004
Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule.
The Journal of biological chemistry
Sawchuk DJ,Mansilla-Soto J,Alarcon C,Singha NC,Langen H,Bianchi ME,Lees-Miller SP,Nussenzweig MC,Cortes P
MA5-13244 was used in western blot to study the role of Ku70/80 and DNA-PK in regulating RAG-mediated cleavage and the significance for the 12/23 rule specificity
Fri Jul 09 00:00:00 EDT 2004
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Nucleic acids research
Onclercq-Delic R,Calsou P,Delteil C,Salles B,Papadopoulo D,Amor-Guéret M
MA5-13244 was used in immunoprecipitation to study the potential anti-recombinogenic role of BLM DNA helicase in double-strand break processing
Sat Nov 01 00:00:00 EST 2003
Biochemical evidence for Ku-independent backup pathways of NHEJ.
Nucleic acids research
Wang H,Perrault AR,Takeda Y,Qin W,Wang H,Iliakis G
MA5-13244 was used in western blot to study alternative backup pathways of non-homologous end joining that are independent of Ku
Mon Sep 15 00:00:00 EDT 2003
Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle.
American journal of physiology. Cell physiology
Lebrasseur NK,Coté GM,Miller TA,Fielding RA,Sawyer DB
MA5-13244 was used in western blot to study the regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle
Thu May 01 00:00:00 EDT 2003
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Head & neck
Friesland S,Kanter-Lewensohn L,Tell R,Munck-Wikland E,Lewensohn R,Nilsson A
MA5-13244 was used in immunohistochemistry to study the correlation between Ku86 expression and favorable outcome in tonsillar carcinoma treated with radiotherapy
Tue Apr 01 00:00:00 EST 2003
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
The Journal of biological chemistry
Udayakumar D,Bladen CL,Hudson FZ,Dynan WS
MA5-13244 was used in western blot to study two biochemically distinct pathways of non-homologous end joining that are differentially regulated by DNA-PK
Fri Oct 24 00:00:00 EDT 2003
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
Cell
Ma Y,Pannicke U,Schwarz K,Lieber MR
MA5-13244 was used in immunoprecipitation and western blot to study the function of an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
Fri Mar 22 00:00:00 EST 2002
Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.
Molecular and cellular biology
Mo X,Dynan WS
MA5-13244 was used in immunocytochemistry to study the sub-nuclear localization of Ku proteins and their association with RNA polymerase II elongation sites
Fri Nov 01 00:00:00 EST 2002
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase.
Molecular and cellular biology
Jhappan C,Yusufzai TM,Anderson S,Anver MR,Merlino G
MA5-13244 was used in western blot to study whether DNA-dependent protein kinase is involved in the p53-mediated response to DNA damage
Thu Jun 01 00:00:00 EDT 2000
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.
The Journal of biological chemistry
Chen L,Trujillo K,Sung P,Tomkinson AE
MA5-13244 was used in western blot to study the interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase
Fri Aug 25 00:00:00 EDT 2000
Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.
Molecular and cellular biology
Giffin W,Gong W,Schild-Poulter C,Haché RJ
MA5-13244 was used in EMSA to study the mechanism by which Ku antigen-DNA conformation modulates the repression of MMTV transcription
Tue Jun 01 00:00:00 EDT 1999
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.
Immunity
Gao Y,Chaudhuri J,Zhu C,Davidson L,Weaver DT,Alt FW
MA5-13244 was used in western blot to study the DNA-PK-independent functions of Ku70 and Ku80 in V(D)J recombination
Tue Sep 01 00:00:00 EDT 1998