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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 180 and 393 of Human DNA polymerase gamma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29676 targets DNA polymerase gamma in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29676 immunogen is recombinant fragment corresponding to a region within amino acids 180 and 393 of Human DNA polymerase gamma.
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
catalytic subunit; DNA polymerase gamma; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; MDP1; MIRAS; Mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma catalytic subunit; MTDPS4A; MTDPS4B; PEO; PolG; PolG-alpha; POLG1; POLGA; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit
MDP1; Mip1; MIRAS; MTDPS4A; MTDPS4B; PEO; POLG; POLG1; POLGA; SANDO; SCAE