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Product Details
H00001794-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2F4
Immunogen
DOCK2 (AAH16996, 1 a.a. approximately 336 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
Sequence of this protein is as follows: MCVCAEDGKT LPVAVPIEDM QRIHLRFMFR HRSSLESKDK GEKNFAMSYV KLMKEDGTTL HDGFHDLVVL KGDSKKMEDA SAYLTLPSYR HHVENKGATL SRSSSSVGGL SVSSRDVFSI STLVCSTKLT QNVGLLGLLK WRMKPQLEES MRRLFESINN LMKSQYKTTI LLQVAALKYI PSVLHDVEMV FDAKLLSQLL YEFYTCIPPV KLQKQKVQSM NEIVQSNLFK KQECRDILLP VITKELKELL EQKDDMQHQV LERKYCVELL NSILEVLSYQ DAAFTYHHIQ EIMVQLLRTV NRTVITMGRD HILIGACCNC GFPSSTPHSL IQWLWG
Target Information
The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dedicator of cyto-kinesis 2; Dedicator of cytokinesis protein 2; FLJ46592
Gene Aliases: DOCK2; IMD40; KIAA0209
UniProt ID: (Human) Q92608
Entrez Gene ID: (Human) 1794
Molecular Function:
guanyl-nucleotide exchange factor
membrane raft polarization
establishment of T cell polarity
immunological synapse formation
myeloid dendritic cell activation involved in immune response
chemotaxis
small GTPase mediated signal transduction
actin cytoskeleton organization
positive regulation of GTPase activity
macropinocytosis
positive thymic T cell selection
negative thymic T cell selection
alpha-beta T cell proliferation
regulation of defense response to virus by virus
positive regulation of phagocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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