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Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dedicator of cyto-kinesis 2; Dedicator of cytokinesis protein 2; FLJ46592
Gene Aliases: DOCK2; IMD40; KIAA0209
UniProt ID: (Human) Q92608
Entrez Gene ID: (Human) 1794
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