Invitrogen

DOCK2 Monoclonal Antibody (OTI7G2)

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DOCK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a DOCK2 monoclonal antibody (Product # MA5-26547).

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Western Blot (WB)

1:2000

Product Specifications

Species Reactivity

Human

Host / Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI7G2

Immunogen

Human recombinant protein fragment corresponding to amino acids 1544-1830 of DOCK2 produced in E.coli

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2723086

Target Information

The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: dedicator of cyto-kinesis 2; dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; FLJ46592; KIAA0209dedicator of cyto-kinesis 2

Gene Aliases: DOCK2; IMD40; KIAA0209

UniProt ID: (Human) Q92608

Entrez Gene ID: (Human) 1794

Molecular Function: G-protein modulator enzyme modulator guanyl-nucleotide exchange factor

Function(s)

membrane raft polarization establishment of T cell polarity immunological synapse formation myeloid dendritic cell activation involved in immune response chemotaxis small GTPase mediated signal transduction actin cytoskeleton organization positive regulation of GTPase activity macropinocytosis positive thymic T cell selection negative thymic T cell selection alpha-beta T cell proliferation regulation of defense response to virus by virus positive regulation of phagocytosis

Process(es)

GTPase activator activity protein binding Rac guanyl-nucleotide exchange factor activity T cell receptor binding

DOCK2 Monoclonal Antibody (OTI7G2)

Product Details

Target Information

Bioinformatics

Material safety data sheets (MSDS)

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