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Invitrogen
DOCK2 Monoclonal Antibody (OTI7G2)
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FIGURE: 1 / 7
DOCK2 Antibody (MA5-26547) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a DOCK2 monoclonal antibody (Product # MA5-26547).
Product Details
MA5-26547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI7G2
Immunogen
Human recombinant protein fragment corresponding to amino acids 1544-1830 of DOCK2 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723086
Target Information
Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dedicator of cyto-kinesis 2; Dedicator of cytokinesis protein 2; FLJ46592
Gene Aliases: DOCK2; IMD40; KIAA0209
UniProt ID: (Human) Q92608
Entrez Gene ID: (Human) 1794
membrane raft polarization
establishment of T cell polarity
immunological synapse formation
myeloid dendritic cell activation involved in immune response
chemotaxis
small GTPase mediated signal transduction
actin cytoskeleton organization
positive regulation of GTPase activity
macropinocytosis
positive thymic T cell selection
negative thymic T cell selection
alpha-beta T cell proliferation
regulation of defense response to virus by virus
positive regulation of phagocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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