MA5-14582 targets Dog1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-14582 immunogen is synthetic peptide of human Dog1.
DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.
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Protein Aliases: anoctamin 1, calcium activated chloride channel; Anoctamin-1; BRCA1-binding helicase-like protein BACH1; Ca2+-activated Cl- channel; calcium activated chloride channel; Discovered on gastrointestinal stromal tumors protein 1; oral cancer overexpressed 2; Oral cancer overexpressed protein 2; Transmembrane protein 16A; transmembrane protein 16A (eight membrane-spanning domains); Tumor-amplified and overexpressed sequence 2
Gene Aliases: ANO1; DOG1; ORAOV2; TAOS2; TMEM16A