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|Tested species reactivity||Bovine, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||SDS denatured, recombinant bovine aromatic DOPA decarboxylase expressed in E. coli and purified from inclusion bodies|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is specific for the ~55 kDa DDC protein in Western blots of rat adrenal medulla.
DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson€™s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AADC; aromatic L-amino acid decarboxylase; aromatic L-amino decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; L-Dopa decarboxylase
AADC; BOS_3968; DDC