Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp586P1823; DOT1 like histone H3K79 methyltransferase; DOT1-like histone H3K79 methyltransferase; DOT1-like protein; DOT1-like, histone H3 methyltransferase; H3-K79-HMTase; Histone H3-K79 methyltransferase; histone methyltransferase DOT1L; Histone-lysine N-methyltransferase, H3 lysine-79 specific; Lysine N-methyltransferase 4
Gene Aliases: DOT1; DOT1L; KIAA1814; KMT4
UniProt ID: (Human) Q8TEK3
Entrez Gene ID: (Human) 84444
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme