|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant DP-1 protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11268 targets DP-1 Transcription Factor in WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11268 immunogen is recombinant DP-1 protein.
DP family contains at least two members, DP-1 and -2. Structurally, DP-1 and -2 are relatively conserved, yet their expression appears to be tissue specific. E2F-1, a functional target for the tumor suppressor protein Rb, heterodimers with DP-1 and forms an active E2F transcriptional complex. The interaction between members of the E2F and the DP families is mediated, in part, by a leucine repeat which is weakly conserved between the two families.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer.
MA5-11268 was used in immunohistochemistry and western blot to study gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer
|Castillo SD,Angulo B,Suarez-Gauthier A,Melchor L,Medina PP,Sanchez-Verde L,Torres-Lanzas J,Pita G,Benitez J,Sanchez-Cespedes M||The Journal of pathology (222:89)||2010|
Building an outcome predictor model for diffuse large B-cell lymphoma.
MA5-11268 was used in immunohistochemistry to develop a protein expression-based model for predicting outcome in patients with diffuse large B-cell lymphoma
|Sáez AI,Sáez AJ,Artiga MJ,Pérez-Rosado A,Camacho FI,Díez A,García JF,Fraga M,Bosch R,Rodríguez-Pinilla SM,Mollejo M,Romero C,Sánchez-Verde L,Pollán M,Piris MA||The American journal of pathology (164:613)||2004|
Dp1 is required for extra-embryonic development.
MA5-11268 was used in immunohistochemistry and western blot to study the essential role of Dp1 in extra-embryonic development.
|Kohn MJ,Bronson RT,Harlow E,Dyson NJ,Yamasaki L||Development (Cambridge, England) (130:1295)||2003|
Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53.
MA5-11268 was used in western blot to study the effect of 5-Fluorouracil on the gene expression of MCF7 breast cancer cells
|Hernández-Vargas H,Ballestar E,Carmona-Saez P,von Kobbe C,Bañón-Rodríguez I,Esteller M,Moreno-Bueno G,Palacios J||International journal of cancer (119:1164)||2006|
Dp1 is largely dispensable for embryonic development.
MA5-11268 was used in western blot to investigate the role of Dp1 in the process of embryonic development
|Kohn MJ,Leung SW,Criniti V,Agromayor M,Yamasaki L||Molecular and cellular biology (24:7197)||2004|
Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.
MA5-11268 was used in EMSA to study the mechanisms by which the HPV-16 E7 protein induces anchorage-independent cell growth
|Schulze A,Mannhardt B,Zerfass-Thome K,Zwerschke W,Jansen-Dürr P||Journal of virology (72:2323)||1998|